Acetic Acid → HCID 68271782, compound

Participants

Reaction Steps

2,2-Dimethylpropionic acid [2-acetyl-4-(tert-butyldimethylsilyloxymethyl)imidazol-1-yl]methylester (1.50 g) was dissolved in THF (50 mL), and at room temperature acetic acid (1 mL) and TBAF (1.0 M THF solution, 4.97 mL) were added, followed by stirring for 4 hours. The reaction solution was concentrated, and the resulting residue was purified by flash chromatography (ethyl acetate/hexane=100%→100%) using silica gel column (product name: Hi-Flash Column 3 L, manufactured by Yamazen Corporation) to afford the title compound (1.10 g).

Provenance & Evidence