HCID 23087457, compound → 6-{2-{{2-[4-(2-Azepan-1-ylethoxy)phenyl]ethyl}ethylamino}phenyl}-5,6,7,8-tetrahydronaphthalen-2-ol

HRID 2423920Notes

Reaction equation

HRID 2423920 reaction equation
C(N(C1C=CC=CC=1C1CCC2C(=CC=C(OC)C=2)C1)CCC1C=CC(O)=CC=1)C.Cl.ClCCN1CCCCCC1.[N:42]1([CH2:49][CH2:50][O:51][C:52]2[CH:57]=[CH:56][C:55]([CH2:58][CH2:59][N:60]([CH2:79][CH3:80])[C:61]3[CH:66]=[CH:65][CH:64]=[CH:63][C:62]=3[CH:67]3[CH2:76][CH2:75][C:74]4[C:69](=[CH:70][CH:71]=[C:72]([O:77]C)[CH:73]=4)[CH2:68]3)=[CH:54][CH:53]=2)[CH2:48][CH2:47][CH2:46][CH2:45][CH2:44][CH2:43]1>>[N:42]1([CH2:49][CH2:50][O:51][C:52]2[CH:53]=[CH:54][C:55]([CH2:58][CH2:59][N:60]([CH2:79][CH3:80])[C:61]3[CH:66]=[CH:65][CH:64]=[CH:63][C:62]=3[CH:67]3[CH2:76][CH2:75][C:74]4[CH:73]=[C:72]([OH:77])[CH:71]=[CH:70][C:69]=4[CH2:68]3)=[CH:56][CH:57]=2)[CH2:48][CH2:47][CH2:46][CH2:45][CH2:44][CH2:43]1

Participants

4

Reactant 3

HCID 23087457HCID 23087457, compoundHCID 24188283N-(2-chloroethyl)perhydroazepine hydrochlorideHCID 66627891{2-[4-(2-Azepan-1-ylethoxy)phenyl]ethyl}ethyl[2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amine

Product 1

HCID 579345396-{2-{{2-[4-(2-Azepan-1-ylethoxy)phenyl]ethyl}ethylamino}phenyl}-5,6,7,8-tetrahydronaphthalen-2-olYield 87.9%

Procedure

Synthesized from 4-{2-{ethyl[2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amino}ethyl}phenol and 1-(2-chloroethyl)azepane hydrochloride according to an analogous synthetic method to Preparation Example 40, {2-[4-(2-azepan-1-ylethoxy)phenyl]ethyl}ethyl[2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amine (298 mg) was used according to an analogous synthetic method to Example 111 to provide the title compound (255 mg).

Sources & evidence

ORD record
ord-b56cd16b3cf442faab71c4a83dd75ce2
Source dataset
uspto-grants-2011_06
Patent number
US07960412B2

Reaction notes

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