HRID2423921

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID18379352

5-(Benzyloxy)pyridine-2-carboxylic acid

C13H11NO3

结构：COc1ccc(C2CCc3cc(OC(=O)C(C)(C)C)ccc3C2)c(NCCC(=O)c2ccc(OCc3ccccc3)cn2)c1

HCID66625776

未命名化合物

PRODUCTS

生成物

结构：CCN(C(=O)c1ccc(O)cn1)c1cc(OC)ccc1C1CCc2cc(OC(=O)C(C)(C)C)ccc2C1

HCID57934579

未命名化合物

PROCEDURE

实验过程

Synthesized from 6-(2-ethylamino-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester and 5-benzyloxypyridine-2-carboxylic acid according to an analogous synthetic method to Example 152, pivalic acid 6-{2-[(5-benzyloxypyridine-2-carbonyl)ethylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (163 mg) was used according to an analogous synthetic method to Example 22 to provide the title compound (124 mg).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-26b347d170764b2abc9b409c6e9a96b8
来源数据集: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07960412B2
来源说明: uspto-grants-2011_06

反应 SMILES

C([O:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]([OH:17])=O)=[N:13][CH:14]=1)C1C=CC=CC=1.C(OC1C=CC(C([CH2:34][CH2:35][NH:36][C:37]2[CH:42]=[C:41]([O:43][CH3:44])[CH:40]=[CH:39][C:38]=2[CH:45]2[CH2:54][CH2:53][C:52]3[CH:51]=[C:50]([O:55][C:56](=[O:61])[C:57]([CH3:60])([CH3:59])[CH3:58])[CH:49]=[CH:48][C:47]=3[CH2:46]2)=O)=NC=1)C1C=CC=CC=1>>[CH2:35]([N:36]([C:15]([C:12]1[CH:11]=[CH:10][C:9]([OH:8])=[CH:14][N:13]=1)=[O:17])[C:37]1[CH:42]=[C:41]([O:43][CH3:44])[CH:40]=[CH:39][C:38]=1[CH:45]1[CH2:54][CH2:53][C:52]2[CH:51]=[C:50]([O:55][C:56](=[O:61])[C:57]([CH3:60])([CH3:59])[CH3:58])[CH:49]=[CH:48][C:47]=2[CH2:46]1)[CH3:34]