5-(Benzyloxy)pyridine-2-carboxylic acid → Pivalic acid 6-{2-[ethyl(5-hydroxypyridine-2-carbonyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester
Reaction equation
C([O:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]([OH:17])=O)=[N:13][CH:14]=1)C1C=CC=CC=1.C(OC1C=CC(C([CH2:34][CH2:35][NH:36][C:37]2[CH:42]=[C:41]([O:43][CH3:44])[CH:40]=[CH:39][C:38]=2[CH:45]2[CH2:54][CH2:53][C:52]3[CH:51]=[C:50]([O:55][C:56](=[O:61])[C:57]([CH3:60])([CH3:59])[CH3:58])[CH:49]=[CH:48][C:47]=3[CH2:46]2)=O)=NC=1)C1C=CC=CC=1>>[CH2:35]([N:36]([C:15]([C:12]1[CH:11]=[CH:10][C:9]([OH:8])=[CH:14][N:13]=1)=[O:17])[C:37]1[CH:42]=[C:41]([O:43][CH3:44])[CH:40]=[CH:39][C:38]=1[CH:45]1[CH2:54][CH2:53][C:52]2[CH:51]=[C:50]([O:55][C:56](=[O:61])[C:57]([CH3:60])([CH3:59])[CH3:58])[CH:49]=[CH:48][C:47]=2[CH2:46]1)[CH3:34]Participants
3
Reactant 2
Product 1
Procedure
Synthesized from 6-(2-ethylamino-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester and 5-benzyloxypyridine-2-carboxylic acid according to an analogous synthetic method to Example 152, pivalic acid 6-{2-[(5-benzyloxypyridine-2-carbonyl)ethylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (163 mg) was used according to an analogous synthetic method to Example 22 to provide the title compound (124 mg).
Sources & evidence
- ORD record
- ord-26b347d170764b2abc9b409c6e9a96b8
- Source dataset
- uspto-grants-2011_06
- Patent number
- US07960412B2
Reaction notes
Loading…