3-Azabicyclo(3.2.2)nonane, 3-(chloroacetyl)- → HCID 66627553, compound

HRID 2423968Notes

Reaction equation

HRID 2423968 reaction equation
C([N:3](C(=O)C1C=CC(O)=CC=1)[C:4]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=1[CH:12]1[CH2:21][CH2:20][C:19]2[CH:18]=[C:17]([O:22]C(=O)C(C)(C)C)[CH:16]=[CH:15][C:14]=2[CH2:13]1)C.[CH:38]12[CH2:46][CH2:45][CH:42]([CH2:43][CH2:44]1)[CH2:41][N:40]([C:47](=O)[CH2:48]Cl)[CH2:39]2>>[CH:38]12[CH2:46][CH2:45][CH:42]([CH2:43][CH2:44]1)[CH2:41][N:40]([CH2:47][CH2:48][O:10][C:8]1[CH:9]=[CH:4][C:5]([CH2:12][CH2:13][CH2:14][NH:3][C:4]3[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=3[CH:12]3[CH2:21][CH2:20][C:19]4[CH:18]=[C:17]([OH:22])[CH:16]=[CH:15][C:14]=4[CH2:13]3)=[CH:6][CH:7]=1)[CH2:39]2

Participants

3

Reactant 2

HCID 143313-Azabicyclo(3.2.2)nonane, 3-(chloroacetyl)-HCID 57934562Pivalic acid 6-{2-[ethyl(4-hydroxybenzoyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester

Product 1

HCID 66627553HCID 66627553, compoundYield 11.8%

Procedure

Synthesized from pivalic acid 6-{2-[ethyl(4-hydroxybenzoyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (26 mg) and 1-(3-azabicyclo[3.2.2]non-3-yl)-2-chloroethanone (21 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (1.7 mg) was obtained.

Workup

  1. custompurified by LC-MS

Sources & evidence

ORD record
ord-d2c5eb14afa3452d839fff42ffb53006
Source dataset
uspto-grants-2011_06
Patent number
US07960412B2

Reaction notes

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