HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-1-(4-methylpiperidin-1-yl)ethan-1-one → 6-{2-{Ethyl {3-fluoro-4-[2-(4-methylpiperidin-1-yl)ethoxy]benzyl}amino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-1-(4-methylpiperidin-1-yl)ethan-1-one | HCID 4116926 | — |
| Reactant | Pivalic acid 6-{2-[ethyl(3-fluoro-4-hydroxybenzoyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester | HCID 57934183 | — |
| Product | 6-{2-{Ethyl {3-fluoro-4-[2-(4-methylpiperidin-1-yl)ethoxy]benzyl}amino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol | HCID 57933974 | 67.9% |
Reaction Steps
Synthesized from pivalic acid 6-{2-[ethyl(3-fluoro-4-hydroxybenzoyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (21 mg) and 2-chloro-1-(4-methylpiperidin-1-yl)ethanone (16 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (15 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07960412B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-d41b342e633a4d4f99127ac7720ad854 |
| Source note | uspto-grants-2011_06 |