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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2424017Generated: October 27, 2026

1-(Chloroacetyl)azocane → 6-{2-{[4-(2-Azocan-1-ylethoxy)benzyl]propylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol

https://huagongshe.com/reaction/2424017

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Chloroacetyl)azocaneHCID 16226899—
ReactantPivalic acid 6-{2-[(4-hydroxybenzoyl)propylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl esterHCID 66626482—
Product6-{2-{[4-(2-Azocan-1-ylethoxy)benzyl]propylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-olHCID 6662590664.8%

Reaction Steps

Synthesized from pivalic acid 6-{2-[(4-hydroxybenzoyl)propylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (30 mg) and 1-azocan-1-yl-2-chloroethanone (22 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (21 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07960412B2
Source datasetuspto-grants-2011_06
ORD IDord-23c520b1e40641f091326f81bb2bea99
Source noteuspto-grants-2011_06