3-Azabicyclo(3.2.2)nonane, 3-(chloroacetyl)- → HCID 66625559, compound

HRID 2424019Notes

Reaction equation

HRID 2424019 reaction equation
[OH:1][C:2]1[CH:38]=[CH:37][C:5]([C:6]([CH2:8][CH2:9][CH2:10][NH:11][C:12]2[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:13]=2[CH:20]2[CH2:29][CH2:28][C:27]3[CH:26]=[C:25]([O:30]C(=O)C(C)(C)C)[CH:24]=[CH:23][C:22]=3[CH2:21]2)=O)=[CH:4][CH:3]=1.[CH:39]12[CH2:47][CH2:46][CH:43]([CH2:44][CH2:45]1)[CH2:42][N:41]([C:48](=O)[CH2:49]Cl)[CH2:40]2>>[CH:39]12[CH2:47][CH2:46][CH:43]([CH2:44][CH2:45]1)[CH2:42][N:41]([CH2:48][CH2:49][O:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH2:8][CH2:9][CH2:10][NH:11][C:12]3[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:13]=3[CH:20]3[CH2:29][CH2:28][C:27]4[CH:26]=[C:25]([OH:30])[CH:24]=[CH:23][C:22]=4[CH2:21]3)=[CH:37][CH:38]=1)[CH2:40]2

Participants

3

Reactant 2

HCID 143313-Azabicyclo(3.2.2)nonane, 3-(chloroacetyl)-HCID 66626482Pivalic acid 6-{2-[(4-hydroxybenzoyl)propylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester

Product 1

HCID 66625559HCID 66625559, compoundYield 41.9%

Procedure

Synthesized from pivalic acid 6-{2-[(4-hydroxybenzoyl)propylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (21 mg) and 1-(3-azabicyclo[3.2.2]non-3-yl)-2-chloroethanone (17 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (9.7 mg) was obtained.

Workup

  1. custompurified by LC-MS

Sources & evidence

ORD record
ord-1046c09863554ba6b4540264c1c7aacb
Source dataset
uspto-grants-2011_06
Patent number
US07960412B2

Reaction notes

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