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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2424060Generated: November 1, 2026

2-chloro-N-ethylacetamide → 6-{2-{Ethyl[4-(2-ethylaminoethoxy)-3-fluorobenzyl]amino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol

https://huagongshe.com/reaction/2424060

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-chloro-N-ethylacetamideHCID 66044—
ReactantPivalic acid 6-{2-[ethyl(3-fluoro-4-hydroxybenzoyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl esterHCID 57934183—
Product6-{2-{Ethyl[4-(2-ethylaminoethoxy)-3-fluorobenzyl]amino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-olHCID 5802306621.1%

Reaction Steps

Synthesized from pivalic acid 6-{2-[ethyl(3-fluoro-4-hydroxybenzoyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (25 mg) and 2-chloro-N-ethylacetamide (11 mg) according to an analogous synthetic method to Example 567 and purified by LC-MS, the title compound (5.0 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07960412B2
Source datasetuspto-grants-2011_06
ORD IDord-c29d1495653e4bee89fbc35c7448b9c9
Source noteuspto-grants-2011_06