HCID 23087560, compound → HCID 57933802, compound

HRID 2424084Notes

Reaction equation

HRID 2424084 reaction equation
C(N(C(=O)C1C=CC(O)=CC=1)C1C=C(OC)[CH:7]=[CH:6][C:5]=1[C@@H:12]1[CH2:21][CH2:20][C:19]2[CH:18]=[C:17]([O:22]C(=O)C(C)(C)C)[CH:16]=[CH:15][C:14]=2[CH2:13]1)C.Cl[CH2:39][C:40]([N:42]([CH2:44][CH2:45][CH2:46][O:47][CH3:48])[CH3:43])=O>>[CH2:40]([N:42]([CH2:43][C:14]1[CH:19]=[CH:18][C:17]([O:22][CH2:39][CH2:40][N:42]([CH2:44][CH2:45][CH2:46][O:47][CH3:48])[CH3:43])=[CH:16][CH:15]=1)[C:44]1[CH:45]=[C:46]([O:47][CH3:48])[CH:7]=[CH:6][C:5]=1[C@@H:12]1[CH2:21][CH2:20][C:19]2[CH:18]=[C:17]([OH:22])[CH:16]=[CH:15][C:14]=2[CH2:13]1)[CH3:39]

Participants

3

Reactant 2

HCID 23087560HCID 23087560, compoundHCID 57934043pivalic acid (R)-6-{2-[ethyl(4-hydroxybenzoyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester

Product 1

HCID 57933802HCID 57933802, compoundYield 110.5%

Procedure

Synthesized from pivalic acid (R)-6-{2-[ethyl(4-hydroxybenzoyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (15 mg) and 2-chloro-N-(3-methoxypropyl)-N-methylacetamide (10 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (8.8 mg) was obtained.

Workup

  1. custompurified by LC-MS

Sources & evidence

ORD record
ord-41966f93fe9848d89e295d372ed1cb2c
Source dataset
uspto-grants-2011_06
Patent number
US07960412B2

Reaction notes

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