2-chloro-N-(2-methoxyethyl)-N-methylacetamide → HCID 57934438, compound

HRID 2424141Notes

Reaction equation

HRID 2424141 reaction equation
[CH2:1]([N:3]([C:27](=O)[C:28]1[CH:33]=[CH:32][C:31]([OH:34])=[CH:30][CH:29]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C@@H:10]1[CH2:19][CH2:18][C:17]2[CH:16]=[C:15]([O:20]C(=O)C(C)(C)C)[CH:14]=[CH:13][C:12]=2[CH2:11]1)[CH3:2].Cl[CH2:37][C:38]([N:40]([CH2:42][CH2:43][O:44][CH3:45])[CH3:41])=O>>[CH2:1]([N:3]([CH2:27][C:28]1[CH:29]=[CH:30][C:31]([O:34][CH2:37][CH2:38][N:40]([CH2:42][CH2:43][O:44][CH3:45])[CH3:41])=[CH:32][CH:33]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C@@H:10]1[CH2:19][CH2:18][C:13]2[CH:14]=[C:15]([OH:20])[CH:16]=[CH:17][C:12]=2[CH2:11]1)[CH3:2]

Participants

3

Reactant 2

HCID 151749132-chloro-N-(2-methoxyethyl)-N-methylacetamideHCID 57934191HCID 57934191, compound

Product 1

HCID 57934438HCID 57934438, compoundYield 42.9%

Procedure

Synthesized from pivalic acid (R)-6-{2-[ethyl(4-hydroxybenzoyl)amino]phenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (18 mg) and 2-chloro-N-(2-methoxyethyl)-N-methylacetamide (13 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (8.0 mg) was obtained.

Workup

  1. custompurified by LC-MS

Sources & evidence

ORD record
ord-3080ed885f1c4732846d44b8ee83256d
Source dataset
uspto-grants-2011_06
Patent number
US07960412B2

Reaction notes

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