3-Buten-1-amine → HCID 66627443, compound

HRID 2424161Notes

Reaction equation

HRID 2424161 reaction equation
[C:1]([CH2:4][C:5]1[CH:41]=[CH:40][C:8]([CH2:9][CH2:10][CH2:11][NH:12][C:13]2[CH:18]=[C:17]([O:19][CH3:20])[C:16]([O:21][CH3:22])=[CH:15][C:14]=2[C@@H:23]2[CH2:32][CH2:31][C:30]3[CH:29]=[C:28]([O:33]C(=O)C(C)(C)C)[CH:27]=[CH:26][C:25]=3[CH2:24]2)=[CH:7][CH:6]=1)(O)=O.[CH2:42]([CH2:45][NH2:46])[CH:43]=[CH2:44]>>[CH2:42]([CH2:45][NH:46][CH2:1][CH2:4][C:5]1[CH:41]=[CH:40][C:8]([CH2:9][CH2:10][CH2:11][NH:12][C:13]2[CH:18]=[C:17]([O:19][CH3:20])[C:16]([O:21][CH3:22])=[CH:15][C:14]=2[C@@H:23]2[CH2:32][CH2:31][C:30]3[CH:29]=[C:28]([OH:33])[CH:27]=[CH:26][C:25]=3[CH2:24]2)=[CH:7][CH:6]=1)[CH:43]=[CH2:44]

Participants

3

Reactant 2

HCID 4437323-Buten-1-amineHCID 86605262HCID 86605262, compound

Product 1

HCID 66627443HCID 66627443, compoundYield 17.7%

Procedure

Synthesized from pivalic acid (R)-6-{2-[(4-carboxymethylbenzyl)ethylamino]-4,5-dimethoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (19 mg) and allylmethylamine (13 mg) according to an analogous synthetic method to Example 715 and purified by LC-MS, the title compound (3.1 mg) was obtained.

Workup

  1. custompurified by LC-MS

Sources & evidence

ORD record
ord-aba1ba387c3f436b93cdb3a7ba81831f
Source dataset
uspto-grants-2011_06
Patent number
US07960412B2

Reaction notes

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