7-Azabicyclo[2.2.1]heptane hydrochloride → HCID 66627748, compound

HRID 2424167Notes

Reaction equation

HRID 2424167 reaction equation
[C:1]([CH2:4][C:5]1[CH:41]=[CH:40][C:8]([CH2:9][CH2:10][CH2:11][NH:12][C:13]2[CH:18]=[C:17]([O:19][CH3:20])[C:16]([O:21][CH3:22])=[CH:15][C:14]=2[C@@H:23]2[CH2:32][CH2:31][C:30]3[CH:29]=[C:28]([O:33]C(=O)C(C)(C)C)[CH:27]=[CH:26][C:25]=3[CH2:24]2)=[CH:7][CH:6]=1)(O)=O.Cl.[CH:43]12[NH:49][CH:46]([CH2:47][CH2:48]1)[CH2:45][CH2:44]2>>[CH:46]12[N:49]([CH2:1][CH2:4][C:5]3[CH:6]=[CH:7][C:8]([CH2:9][CH2:10][CH2:11][NH:12][C:13]4[CH:18]=[C:17]([O:19][CH3:20])[C:16]([O:21][CH3:22])=[CH:15][C:14]=4[C@@H:23]4[CH2:32][CH2:31][C:30]5[CH:29]=[C:28]([OH:33])[CH:27]=[CH:26][C:25]=5[CH2:24]4)=[CH:40][CH:41]=3)[CH:43]([CH2:48][CH2:47]1)[CH2:44][CH2:45]2

Participants

3

Reactant 2

HCID 162795037-Azabicyclo[2.2.1]heptane hydrochlorideHCID 86605262HCID 86605262, compound

Product 1

HCID 66627748HCID 66627748, compoundYield 13.1%

Procedure

Synthesized from pivalic acid (R)-6-{2-[(4-carboxymethylbenzyl)ethylamino]-4,5-dimethoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (19 mg) and 7-azabicyclo[2.2.1]heptane hydrochloride (20 mg) according to an analogous synthetic method to Example 715 and purified by LC-MS, the title compound (2.4 mg) was obtained.

Workup

  1. custompurified by LC-MS

Sources & evidence

ORD record
ord-0242554c944e4b26b60d480045377800
Source dataset
uspto-grants-2011_06
Patent number
US07960412B2

Reaction notes

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