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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2424170Generated: November 1, 2026

Pyrrolidine → (R)-6-{2-{Ethyl[4-(2-pyrrolidin-1-ylethyl)benzyl]amino}phenyl}-5,6,7,8-tetrahydronaphthalen-2-ol

https://huagongshe.com/reaction/2424170

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPyrrolidineHCID 31268—
ReactantPivalic acid (R)-6-{2-[(4-carboxymethylbenzyl)ethylamino]phenyl}-5,6,7,8-tetrahydronaphthalen-2-yl esterHCID 86605264—
Product(R)-6-{2-{Ethyl[4-(2-pyrrolidin-1-ylethyl)benzyl]amino}phenyl}-5,6,7,8-tetrahydronaphthalen-2-olHCID 5793458986.3%

Reaction Steps

Synthesized from pivalic acid (R)-6-{2-[(4-carboxymethylbenzyl)ethylamino]phenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (28 mg) and pyrrolidine (20 mg) according to an analogous synthetic method to Example 715 and purified by LC-MS, the title compound (11 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07960412B2
Source datasetuspto-grants-2011_06
ORD IDord-5ac7eff80be346ee8fc1612dd881be78
Source noteuspto-grants-2011_06