Piperidine, 1-(2-chloroethyl)-, hydrochloride → HCID 11754059, compound

HRID 2424182Notes

Reaction equation

HRID 2424182 reaction equation
COC1C=CC(CC(C2C=CC(OC)=CC=2)(C)C)=C(C=1)OC1C=CC(O)=CC=1.Cl.ClCCN1CCCCC1.C[O:40][C:41]1[CH:42]=[CH:43][C:44]([CH2:63][C:64]([C:67]2[CH:72]=[CH:71][C:70]([O:73]C)=[CH:69][CH:68]=2)([CH3:66])[CH3:65])=[C:45]([CH:62]=1)[O:46][C:47]1[CH:61]=[CH:60][C:50]([O:51][CH2:52][CH2:53][N:54]2[CH2:59][CH2:58][CH2:57][CH2:56][CH2:55]2)=[CH:49][CH:48]=1>>[OH:73][C:70]1[CH:71]=[CH:72][C:67]([C:64]([CH3:66])([CH3:65])[CH2:63][C:44]2[CH:43]=[CH:42][C:41]([OH:40])=[CH:62][C:45]=2[O:46][C:47]2[CH:61]=[CH:60][C:50]([O:51][CH2:52][CH2:53][N:54]3[CH2:55][CH2:56][CH2:57][CH2:58][CH2:59]3)=[CH:49][CH:48]=2)=[CH:68][CH:69]=1

Participants

4

Reactant 3

HCID 74826Piperidine, 1-(2-chloroethyl)-, hydrochlorideHCID 11153156HCID 11153156, compoundHCID 23087276HCID 23087276, compound

Product 1

HCID 11754059HCID 11754059, compoundYield 65.9%

Procedure

Synthesized from 4-{5-methoxy-2-[2-(4-methoxyphenyl)-2-methylpropyl]phenoxy}phenol and 1-(2-chloroethyl)piperidine hydrochloride according to an analogous synthetic method to Preparation Example 40, 1-{2-{4-{5-methoxy-2-[2-(4-methoxyphenyl)-2-methylpropyl]phenoxy}phenoxy}ethyl}piperidine (190 mg) was used according to an analogous synthetic method to Example 779 described below to provide the title compound (118 mg).

Sources & evidence

ORD record
ord-4734433cf6e34d539ceb158f20deeadc
Source dataset
uspto-grants-2011_06
Patent number
US07960412B2

Reaction notes

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