1,3-Dimethoxybenzene → 1-(2,4-Dimethoxyphenyl)-2-(4-methoxyphenyl)ethanone

HRID 2424190Notes

Reaction equation

HRID 2424190 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[CH:4]=1.[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([CH2:19][C:20](Cl)=[O:21])=[CH:15][CH:14]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([O:9][CH3:10])[CH:6]=[CH:7][C:8]=1[C:20](=[O:21])[CH2:19][C:16]1[CH:17]=[CH:18][C:13]([O:12][CH3:11])=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 90251,3-DimethoxybenzeneHCID 27346884-Methoxyphenylacetyl chloride

Product 1

HCID 134271631-(2,4-Dimethoxyphenyl)-2-(4-methoxyphenyl)ethanoneYield 51.6%

Procedure

Synthesized from 1,3-dimethoxybenzene (8.2 g) and 4-methoxyphenylacetyl chloride (10.0 g) according to an analogous synthetic method to Preparation Example 66, the title compound (8.0 g) was obtained.

Workup

  1. customaccording to an analogous synthetic method to Preparation Example 66

Sources & evidence

ORD record
ord-de09f0cc7e144fcb9aa212cad5f63fda
Source dataset
uspto-grants-2011_06
Patent number
US07960412B2

Reaction notes

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