反应详情

温度

-78 °C

To a solution of 1-bromo-2-isopropyl-4-methoxy-benzene (Intermediate 143, 2.20 g, 9.60 mmols) in 50 mL CH2Cl2 at −78° C. was added BBr3 (4.81 g, 19.2 mmols; 19.2 mL of a 1M solution in CH2Cl2). After stirring for 3 hours at −78° C. the solution was warmed to 0° C. for 3 hours and then at 25° C. for 1 hour before being quenched with H2O. The mixture was diluted with Et2O and washed with H2O and saturated aqueous NaCl, dried (Na2SO4) and concentrated under reduced pressure. Column chromatography (2.5-10% EtOAc—hexanes) afforded the title compound as a colorless oil.

1. temperaturewas warmed to 0° C. for 3 hours
2. customat 25° C. for 1 hour before being quenched with H2O
3. additionThe mixture was diluted with Et2O
4. washwashed with H2O and saturated aqueous NaCl
5. dry with materialdried (Na2SO4)
6. concentrationconcentrated under reduced pressure