4-(2-Azepan-1-ylethoxy)benzoic acid hydrochloride → [4-(2-Azepan-1-ylethoxy)benzyl][6-methoxy-2-(4-methoxyphenyl)indan-4-yl]methyl amine

Participants

Role	Name	HCID	Charge
Reactant	4-(2-Azepan-1-ylethoxy)benzoic acid hydrochloride	HCID 13174870	—
Reactant	(4-Benzyloxybenzyl)[6-methoxy-2-(4-methoxyphenyl)indan-4-yl]methylamine	HCID 66626750	—
Reactant	[6-Methoxy-2-(4-methoxyphenyl)indan-4-yl]methylamine	HCID 86605266	—
Product	[4-(2-Azepan-1-ylethoxy)benzyl][6-methoxy-2-(4-methoxyphenyl)indan-4-yl]methyl amine	HCID 66627713	—

Reaction Steps

Synthesized from (4-benzyloxybenzyl)[6-methoxy-2-(4-methoxyphenyl)indan-4-yl]methylamine according to an analogous synthetic method to Example 22, [6-methoxy-2-(4-methoxyphenyl)indan-4-yl]methylamine (553 mg) and 4-(2-azepan-1-ylethoxy)benzoic acid hydrochloride (795 mg) were used according to an analogous synthetic method to Example 152 to provide [4-(2-azepan-1-ylethoxy)benzyl][6-methoxy-2-(4-methoxyphenyl)indan-4-yl]methyl amine (172 mg). This compound was used according to an analogous synthetic method to Example 111 to provide the title compound (64 mg).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07960412B2
Source dataset	uspto-grants-2011_06
ORD ID	ord-8de9ff6443854581a8ae7068597676d8
Source note	uspto-grants-2011_06