Benzylamine → HCID 57934345, compound

HRID 2424207Notes

Reaction equation

HRID 2424207 reaction equation
FC(F)(F)S(OC1C=CC=CC=1CC1CCC2C(=CC=C(OC)C=2)C1)(=O)=O.C(N)C1C=CC=CC=1.[CH2:36]([NH:43][C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][C:45]=1[CH2:50][CH:51]1[CH2:60][CH2:59][C:58]2[C:53](=[CH:54][CH:55]=[C:56]([O:61]C)[CH:57]=2)[CH2:52]1)[C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1>>[CH2:36]([NH:43][C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][C:45]=1[CH2:50][CH:51]1[CH2:60][CH2:59][C:58]2[CH:57]=[C:56]([OH:61])[CH:55]=[CH:54][C:53]=2[CH2:52]1)[C:37]1[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=1

Participants

4

Reactant 3

HCID 7504BenzylamineHCID 23087246HCID 23087246, compoundHCID 23087537HCID 23087537, compound

Product 1

HCID 57934345HCID 57934345, compound

Procedure

Synthesized from 2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)phenyl trifluoromethanesulfonate (1.4 g) and benzylamine (650 mg) according to an analogous synthetic method to Example 116, benzyl[2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)phenyl]amine was used according to an analogous synthetic method to Example 785 to provide the title compound (440 mg).

Sources & evidence

ORD record
ord-a21798ccf50b4fffbef428f2fadf8e43
Source dataset
uspto-grants-2011_06
Patent number
US07960412B2

Reaction notes

Loading…