Benzyl Alcohol → Benzyl 4-carboxyphenylacetate

HRID 2424224Notes

Reaction equation

HRID 2424224 reaction equation
C(C1C=CC(CC(O)=O)=CC=1)=[O:2].C(O)C1C=CC=CC=1.[CH:21]([C:23]1[CH:28]=[CH:27][C:26]([CH2:29][C:30]([O:32][CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)=[O:31])=[CH:25][CH:24]=1)=[O:22]>>[CH2:33]([O:32][C:30]([CH2:29][C:26]1[CH:25]=[CH:24][C:23]([C:21]([OH:2])=[O:22])=[CH:28][CH:27]=1)=[O:31])[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1

Participants

4

Reactant 3

HCID 244Benzyl AlcoholHCID 113441872-(4-formylphenyl)acetic AcidHCID 19966221Benzyl 2-(4-formylphenyl)acetate

Product 1

HCID 19966080Benzyl 4-carboxyphenylacetateYield 80.6%

Procedure

Synthesized from (4-formylphenyl)acetic acid (1 g) and benzyl alcohol (730 mg) according to an analogous synthetic method to Example 806, benzyl (4-formylphenyl)acetate (1.4 g) was used according to an analogous synthetic method to Preparation Example 53 to provide the title compound (1.2 g).

Workup

  1. customwas used according to an analogous synthetic method to Preparation Example 53

Sources & evidence

ORD record
ord-fdfd933d4e5d4a048180ac237136aadb
Source dataset
uspto-grants-2011_06
Patent number
US07960412B2

Reaction notes

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