Acetate → Octreotide

Participants

Reaction Steps

Poly(DL-lactide-co-glycolide) (PLGA) having a 50/50 ratio of lactide to glycolide (DL2.5A from Alkermes) was dissolved in N-methyl-2-pyrrolidone (NMP), or methoxypolyethylene glycohol (mPEG) to give a 40% solution by weight. The injectable polymer solutions were prepared by dispersing octreotide phytate or acetate or citrate. The mixture was thoroughly mixed until a uniform suspension or solution was obtained. Injectable formulations were prepared as shown below.

Provenance & Evidence