HCID 59129757, compound → HCID 11276477, compound

Participants

Reaction Steps

Zinc dust (23.71 g, 0.58 mol) was added to a stirred solution of compound 31 (theorical: 58.4 mmol) in AcOH (110 ml) at 0° C. After 1 hour, the reaction mixture was filtered through a Celite pad. The filtrate was diluted with AcOEt and cold water. The pH was adjusted to 7 and the layers were separated. The aqueous phase was extracted again with AcOEt. Organic layers were dried over Na2SO4 and concentrated. The beige solid was cristallized in AcOEt and afforded 2-(5-chloro-2-oxo-2,3-dihydro-1H-indol-1-yl)propanamide 32 as a white solid.

Provenance & Evidence