HCID 58304318, compound → HCID 58304315, compound

Participants

Reaction Steps

Intermediate Fa3 (R1,2=cyclopropyl, R3=Me): A suspension of (S)-8-(2-fluoro-5-nitro-phenyl)-8-methyl-5-oxa-7-aza-spiro[2.5]oct-6-en-6-ylamine (279 mg) in ethyl alcohol (25 ml), NEt3 (0.10 ml) and Pd/C (10%, 50 mg) was hydrogenated at normal pressure and 22° C. for 1 h. The mixture was filtered, the filtrate evaporated and the residue triturated with ether to give (S)-8-(5-amino-2-fluoro-phenyl)-8-methyl-5-oxa-7-aza-spiro[2.5]oct-6-en-6-ylamine (213 mg) as a pale yellow solid. MS (ESI): m/z=250.1 [M+H]+.

Provenance & Evidence