HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluorothiophene-2-carboxylic acid → 5-Fluoro-thiophene-2-carboxylic acid [3-((S)-2-amino-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluorothiophene-2-carboxylic acid | HCID 11804901 | — |
| Reactant | [(S)-4-(5-amino-2-fluoro-phenyl)-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-yl]-carbamic acid tert-butyl ester | HCID 67234727 | — |
| Product | 5-Fluoro-thiophene-2-carboxylic acid [3-((S)-2-amino-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide | HCID 53241247 | — |
Reaction Steps
The coupling of [(S)-4-(5-amino-2-fluoro-phenyl)-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-yl]-carbamic acid tert-butyl ester from experiment F1 (R3=Me) and 5-fluoro-thiophene-2-carboxylic acid followed by deprotection using procedure H yielded the title compound. MS (ESI): m/z=352.0 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07964594B1 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-33948ed75c1e45aab81a52761b5f110f |
| Source note | uspto-grants-2011_06 |