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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2424356Generated: November 1, 2026

5-Methylthiophene-2-carboxylic acid → HCID 53241351, compound

https://huagongshe.com/reaction/2424356

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Methylthiophene-2-carboxylic acidHCID 74713—
Reactant[(S)-4-(5-amino-2-fluoro-phenyl)-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-yl]-carbamic acid tert-butyl esterHCID 67234727—
ProductHCID 53241351HCID 53241351—

Reaction Steps

The coupling of [(S)-4-(5-amino-2-fluoro-phenyl)-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-yl]-carbamic acid tert-butyl ester from experiment F1 (R3=Me) and 5-methyl-thiophene-2-carboxylic acid followed by deprotection using procedure H yielded the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07964594B1
Source datasetuspto-grants-2011_06
ORD IDord-5223cb2b90204db3b8378a7f241290f1
Source noteuspto-grants-2011_06