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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2424364Generated: October 30, 2026

3,5-Difluoropyridine-2-carboxylic acid → HCID 53241660, compound

https://huagongshe.com/reaction/2424364

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,5-Difluoropyridine-2-carboxylic acidHCID 2783262—
Reactant[(S)-4-(5-amino-2-fluoro-phenyl)-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-yl]-carbamic acid tert-butyl esterHCID 67234727—
ProductHCID 53241660HCID 53241660—

Reaction Steps

The coupling of [(S)-4-(5-amino-2-fluoro-phenyl)-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-yl]-carbamic acid tert-butyl ester from experiment F1 (R1=Me) and 3,5-difluoro-pyridine-2-carboxylic acid followed by deprotection using procedure H yielded the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07964594B1
Source datasetuspto-grants-2011_06
ORD IDord-cd55e71cc7dd4920b4bee617d69b445d
Source noteuspto-grants-2011_06