Sodium borohydride → HCID 57436182, compound

Participants

Reaction Conditions

Reaction Steps

To a cold (0° C.) and stirred mixture of the tert-butyl 4-(2-methylquinolin-5-yl)piperazine-1-carboxylate prepared in example 6 (4.29 g, 13.1 mmol) and NiCl2.6H2O (0.78 g, 3.3 mmol) in MeOH (250 mL) was added portionwise NaBH4 (3.96 g, 104.8 mmol) and then stirring was continued for 3 h. NaBH4 was added when necessary. The solvent was evaporated in vacuo, the residue was treated with water and then extracted with CH2Cl2. After drying over MgSO4, the solvent was evaporated in vacuo and the residue was purified by column chromatography (eluent CH2Cl2) to afford title compound (2.8 g, 51%). Rf 0.85 (CH2Cl2-MeOH 19:1).

Provenance & Evidence