Methyl iodide → HCID 25206091, compound

Participants

Reaction Conditions

Reaction Steps

0.26 g (0.52 mmol) of 1,2,3,4-tetrahydro-2-methyl-5-(piperazin -1-yl)-1-(4-methylbenzenesulfonyl)quinoline prepared in example 14 and 67 mg (1.56 mmol, 45%) NaH was dissolved in 2 mL DMF at 0° C. After stirring 1 h at 0° C., the mixture was cooled to −78° C. and MeI was added (32 μL, 0.52 mmol). The reaction mixture was stirred over 1 night at room temperature After evaporating the solvent, the residue was dissolved in 15 mL water and extracted with EtOAc. The crude product was purified by column chromatography (eluent: CH2Cl2-MeOH 0.5%). Yield: 82 mg (38%) Rf=0.65 (CH2Cl2-MeOH 9:1).

Provenance & Evidence