4-(4-Methoxyphenyl)butyric acid → HCID 16035878, compound

HRID 2424439Notes

Reaction equation

HRID 2424439 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][CH2:11][C:12]([OH:14])=O)=[CH:5][CH:4]=1.[NH2:15][C:16]1[N:21]=[N:20][C:19]([N:22]2[CH2:27][CH2:26][N:25]([C:28]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=3[C:36]([F:39])([F:38])[F:37])=[O:29])[CH2:24][CH2:23]2)=[CH:18][CH:17]=1>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:9][CH2:10][CH2:11][C:12]([NH:15][C:16]2[N:21]=[N:20][C:19]([N:22]3[CH2:23][CH2:24][N:25]([C:28](=[O:29])[C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=4[C:36]([F:39])([F:38])[F:37])[CH2:26][CH2:27]3)=[CH:18][CH:17]=2)=[O:14])=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 782804-(4-Methoxyphenyl)butyric acidHCID 66849536[4-(6-Aminopyridazin-3-yl)piperazin-1-yl](2-trifluoromethylphenyl)methanone

Product 1

HCID 16035878HCID 16035878, compound

Procedure

Following the procedure of Example 1, making variations only as required to use 4-(4-methoxyphenyl)butyric acid in place of 4-methylpentanoic acid to react with [4-(6-aminopyridazin-3-yl)piperazin-1-yl](2-trifluoromethylphenyl)-methanone, the title compound was obtained as a white powder (20% yield). 1H NMR (300 MHz, CDCl3) δ 9.14, 8.29, 7.67, 7.55, 7.49, 7.30, 7.01, 6.98, 6.73, 3.95-3.91, 3.86-3.81, 3.70, 3.61-3.55, 3.48-3.45, 3.26-3.24, 2.57, 2.45, 1.96.

Sources & evidence

ORD record
ord-85e69aee4d2c451bb6bb22e2d5629c6c
Source dataset
uspto-grants-2011_06
Patent number
US07964591B2

Reaction notes

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