[4-(6-Aminopyridazin-3-yl)piperazin-1-yl](2-trifluoromethylphenyl)methanone → HCID 86597208, compound

HRID 2424448Notes

Reaction equation

HRID 2424448 reaction equation
[F:1][C:2]([F:11])([F:10])[CH2:3][CH2:4][O:5][CH2:6][C:7]([OH:9])=O.[NH2:12][C:13]1[N:18]=[N:17][C:16]([N:19]2[CH2:24][CH2:23][N:22]([C:25]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=3[C:33]([F:36])([F:35])[F:34])=[O:26])[CH2:21][CH2:20]2)=[CH:15][CH:14]=1>>[F:36][C:33]([F:34])([F:35])[C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=1[C:25]([N:22]1[CH2:21][CH2:20][N:19]([C:16]2[N:17]=[N:18][C:13]([NH:12][C:7](=[O:9])[CH2:6][O:5][CH2:4][CH2:3][C:2]([F:1])([F:11])[F:10])=[CH:14][CH:15]=2)[CH2:24][CH2:23]1)=[O:26]

Participants

3

Reactant 2

HCID 66849536[4-(6-Aminopyridazin-3-yl)piperazin-1-yl](2-trifluoromethylphenyl)methanoneHCID 82956127HCID 82956127, compound

Product 1

HCID 86597208HCID 86597208, compound

Procedure

Following the procedure of Example 2, making variations only as required to use (3,3,3-trifluoropropoxy)acetic acid in place of benzyloxyacetic acid to react with [4-(6-aminopyridazin-3-yl)piperazin-1-yl](2-trifluoromethylphenyl)methanone, the title compound was obtained as a white powder (50% yield). 1H NMR (300 MHz, CDCl3) δ 9.03, 8.32, 7.75, 7.63, 7.56, 7.37, 7.03, 4.13, 4.03-3.98, 3.94-3.89, 3.84, 3.71-3.63, 3.60-3.58, 3.35-3.32, 2.56-2.48. MS (ES+) m/z 506.5 (M+1).

Sources & evidence

ORD record
ord-78fa0e236cf94f94a6990e99dbfa7143
Source dataset
uspto-grants-2011_06
Patent number
US07964591B2

Reaction notes

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