HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluoro-2-(trifluoromethyl)benzoyl chloride → 6-(4-(5-Fluoro-2-trifluoromethylbenzoyl)piperazin-1-yl)pyridazine-3-carboxylic acid (2-cyclopropylethyl)amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluoro-2-(trifluoromethyl)benzoyl chloride | HCID 2737560 | — |
| Reactant | N-(2-cyclopropylethyl)-6-(1-piperazinyl)-3-pyridazinecarboxamide | HCID 66849327 | — |
| Product | 6-(4-(5-Fluoro-2-trifluoromethylbenzoyl)piperazin-1-yl)pyridazine-3-carboxylic acid (2-cyclopropylethyl)amide | HCID 16035876 | — |
Reaction Steps
Following the procedure of Example 3, making variations only as required to use 5-fluoro-2-trifluoromethylbenzoyl chloride in place of isoxazole-5-carbonyl chloride to react with 6-piperazin-1-yl-pyridazine-3-carboxylic acid (2-cyclopropylethyl)amide, the title compound was obtained as a white powder (65% yield). 1H NMR (400 MHz, CDCl3) δ 8.05, 7.98, 7.74, 7.27-7.24, 7.09-7.06, 7.00, 4.08-3.96, 3.94-3.68, 3.55, 3.36, 1.50, 0.79-0.69, 0.48-0.42, 0.11-0.09.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07964591B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-4515e28cb96d449eb8f720fbbfaa68ee |
| Source note | uspto-grants-2011_06 |