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HRID 2424473作成日：2026年10月25日

2,5-Difluorobenzoyl chloride → 6-[4-(2,5-DIFLUOROBENZOYL)PIPERAZIN-1-YL]PYRIDAZINE-3-CARBOXYLIC Acid (2-CYCLOPROPYLETHYL)AMIDE

https://huagongshe.com/reaction/2424473

反応式

関与物質

役割名称HCID仕込み量
反応物2,5-Difluorobenzoyl chlorideHCID 588082—
反応物N-(2-cyclopropylethyl)-6-(1-piperazinyl)-3-pyridazinecarboxamideHCID 66849327—
生成物6-[4-(2,5-DIFLUOROBENZOYL)PIPERAZIN-1-YL]PYRIDAZINE-3-CARBOXYLIC Acid (2-CYCLOPROPYLETHYL)AMIDEHCID 11223757—

反応手順

Following the procedure of Example 3, making variations only as required to use 2,5-difluorobenzoyl chloride in place of isoxazole-5-carbonyl chloride to react with 6-piperazin-1-yl-pyridazine-3-carboxylic acid (2-cyclopropylethyl)-amide, the title compound was obtained as a white powder (53% yield). 1H NMR (400 MHz, CDCl3) δ 8.08, 8.0, 7.17-7.11, 7.03, 4.02-3.92, 3.85-3.83, 3.59-3.5, 1.52, 0.74-0.69, 0.46-0.40, 0.09-0.04.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07964591B2
出典データセットuspto-grants-2011_06
ORD IDord-8b3bc50fba8d47638048d3cd1cad6ced
出典メモuspto-grants-2011_06