6-Piperazin-1-yl-pyridazin-3-carboxylic acid (3-methylbutyl)amide → HCID 86597218, compound

HRID 2424518Notes

Reaction equation

HRID 2424518 reaction equation
[CH2:1]([N:8]1[C:12]([C:13]([F:16])([F:15])[F:14])=[C:11]([C:17]([OH:19])=O)[N:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:20][CH:21]([CH3:39])[CH2:22][CH2:23][NH:24][C:25]([C:27]1[N:28]=[N:29][C:30]([N:33]2[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]2)=[CH:31][CH:32]=1)=[O:26]>>[CH3:20][CH:21]([CH3:39])[CH2:22][CH2:23][NH:24][C:25]([C:27]1[N:28]=[N:29][C:30]([N:33]2[CH2:38][CH2:37][N:36]([C:17]([C:11]3[N:10]=[N:9][N:8]([CH2:1][C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=4)[C:12]=3[C:13]([F:14])([F:15])[F:16])=[O:19])[CH2:35][CH2:34]2)=[CH:31][CH:32]=1)=[O:26]

Participants

3

Reactant 2

HCID 668493226-Piperazin-1-yl-pyridazin-3-carboxylic acid (3-methylbutyl)amideHCID 66849727HCID 66849727, compound

Product 1

HCID 86597218HCID 86597218, compound

Procedure

Following the procedure of Example 9, making variations only as required to use 1-benzyl-5-trifluoromethyl-1H-[1,2,3]triazole-4-carboxylic acid in place of 2,5-dichlorobenzoic acid to react with 6-piperazin-1-yl-pyridazine-3-carboxylic acid (3-methylbutyl)amide, the title compound was obtained as a white powder (32% yield). 1H NMR (300 MHz, DMSO-d6) δ 8.03, 7.81, 7.33-7.27, 6.86, 5.92, 5.39, 3.71, 3.47, 3.05, 2.63, 2.43, 1.65, 1.48, 0.92. MS (ES+) m/z 531.2 (M+1).

Sources & evidence

ORD record
ord-ea380373f6784bd1b556a58bdc504228
Source dataset
uspto-grants-2011_06
Patent number
US07964591B2

Reaction notes

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