2-(Trifluoromethyl)cyclopropane-1-carboxylic acid → 6-[4-(2-TRIFLUOROMETHYLCYCLOPROPANECARBONYL)PIPERAZIN-1-YL]-PYRIDAZINE-3-CARBOXYLIC Acid (2-CYCLOPROPYLETHYL)AMIDE

HRID 2424535Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2424535
[F:1][C:2]([F:10])([F:9])[CH:3]1[CH2:5][CH:4]1[C:6](O)=[O:7].[CH:11]1([CH2:14][CH2:15][NH:16][C:17]([C:19]2[N:20]=[N:21][C:22]([N:25]3[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]3)=[CH:23][CH:24]=2)=[O:18])[CH2:13][CH2:12]1>>[CH:11]1([CH2:14][CH2:15][NH:16][C:17]([C:19]2[N:20]=[N:21][C:22]([N:25]3[CH2:30][CH2:29][N:28]([C:6]([CH:4]4[CH2:5][CH:3]4[C:2]([F:10])([F:9])[F:1])=[O:7])[CH2:27][CH2:26]3)=[CH:23][CH:24]=2)=[O:18])[CH2:13][CH2:12]1

Komponenten

3

Edukt 2

HCID 133799352-(Trifluoromethyl)cyclopropane-1-carboxylic acidHCID 66849327N-(2-cyclopropylethyl)-6-(1-piperazinyl)-3-pyridazinecarboxamide

Produkt 1

HCID 112584056-[4-(2-TRIFLUOROMETHYLCYCLOPROPANECARBONYL)PIPERAZIN-1-YL]-PYRIDAZINE-3-CARBOXYLIC Acid (2-CYCLOPROPYLETHYL)AMIDE

Versuchsvorschrift

Following the procedure of Example 9, making variations only as required to use 2-trifluoromethylcyclopropanecarboxylic acid in place of 2,5-dichlorobenzoic acid to react with 6-piperazin-1-yl-pyridazine-3-carboxylic acid (2-cyclopropylethyl)amide, the title compound was obtained as a white powder (30.9% yield). 1H NMR (300 MHz, CDCl3) δ 8.03, 7.98, 7.00, 3.97-3.57, 2.20, 1.65, 1.50, 1.26, 0.75, 0.46, 0.09. MS (ES+) m/z 412 (M+1).

Quellen und Nachweise

ORD-Eintrag
ord-6ee8367f26384258b45614f4c8024e76
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07964591B2

Notizen zur Reaktion

Wird geladen…