HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Chloromethyl)-4-fluoro-2-(trifluoromethyl)benzene → HCID 11465123, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Chloromethyl)-4-fluoro-2-(trifluoromethyl)benzene | HCID 2759167 | — |
| Reactant | N-(2-cyclopropylethyl)-6-(1-piperazinyl)-3-pyridazinecarboxamide | HCID 66849327 | — |
| Product | HCID 11465123 | HCID 11465123 | — |
Reaction Steps
Following the procedure of Example 11, making variations only as required to use 4-fluoro-2-trifluoromethylbenzyl chloride in place of 2-trifluoromethylbenzyl chloride to react with 6-piperazin-1-ylpyridazine-3-carboxylic acid (2-cyclopropylethyl)amide, the title compound was obtained as a white solid (38% yield). 1H NMR (300 MHz, CDCl3) δ 7.96-8.04, 7.81, 7.36, 7.20-7.29, 6.96, 3.76, 3.68, 3.56, 2.61, 1.51, 0.68-0.84, 0.43-0.51, 0.06-0.13. MS (ES+) m/z 452 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07964591B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-7ccda8540d4c470ba4f3c8a8fd8093ce |
| Source note | uspto-grants-2011_06 |