1-[2-(Trifluoromethyl)benzoyl]piperazine → HCID 67011419, compound

HRID 2424588Notes

Reaction equation

HRID 2424588 reaction equation
[OH:1][CH:2]([C:15]([CH3:18])([CH3:17])[CH3:16])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[N:9]=[N:10][C:11](Cl)=[CH:12][CH:13]=1)=[O:7].[N:19]1([C:25]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2[C:33]([F:36])([F:35])[F:34])=[O:26])[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[OH:1][CH:2]([C:15]([CH3:18])([CH3:17])[CH3:16])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[N:9]=[N:10][C:11]([N:22]2[CH2:23][CH2:24][N:19]([C:25](=[O:26])[C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=3[C:33]([F:36])([F:34])[F:35])[CH2:20][CH2:21]2)=[CH:12][CH:13]=1)=[O:7]

Participants

3

Reactant 2

HCID 167337841-[2-(Trifluoromethyl)benzoyl]piperazineHCID 86025970HCID 86025970, compound

Product 1

HCID 67011419HCID 67011419, compound

Procedure

Following the procedure of Example 15, making variations only as required to use 6-chloropyridazine-3-carboxylic acid (3-hydroxy-4,4-dimethylpentyl)amide in place of 6-chloropyridazine-3-carboxylic acid (2-cyclopropyl-2-hydroxyethyl)amide to react with piperazin-1-yl-(2-trifluoromethylphenyl)methanone, the title compound was obtained as a white powder (39% yield). 1H NMR (500 MHz, CDCl3) δ 8.18, 8.05, 7.74, 7.63, 7.56, 7.36, 6.99, 4.05, 3.92-3.67, 3.45-3.32, 3.26, 1.76, 1.55, 0.88. MS (ES+) m/z 494 (M+1).

Sources & evidence

ORD record
ord-c7a3c37f28c04ddc80303ad7721bf0e6
Source dataset
uspto-grants-2011_06
Patent number
US07964591B2

Reaction notes

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