6-chloro-N-(3-methylbutyl)pyridazine-3-carboxamide → HCID 11719682, compound

HRID 2424599Notes

Reaction equation

HRID 2424599 reaction equation
[CH3:1][CH:2]([CH3:15])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[N:9]=[N:10][C:11](Cl)=[CH:12][CH:13]=1)=[O:7].[N:16]1([C:22]([C:24]2[C:29]([F:30])=[CH:28][CH:27]=[CH:26][C:25]=2[C:31]([F:34])([F:33])[F:32])=[O:23])[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>>[CH3:1][CH:2]([CH3:15])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[N:9]=[N:10][C:11]([N:19]2[CH2:20][CH2:21][N:16]([C:22](=[O:23])[C:24]3[C:25]([C:31]([F:33])([F:32])[F:34])=[CH:26][CH:27]=[CH:28][C:29]=3[F:30])[CH2:17][CH2:18]2)=[CH:12][CH:13]=1)=[O:7]

Participants

3

Reactant 2

HCID 167337866-chloro-N-(3-methylbutyl)pyridazine-3-carboxamideHCID 66849975HCID 66849975, compound

Product 1

HCID 11719682HCID 11719682, compound

Procedure

Following the procedure of Example 15, making variations only as required to use 6-chloropyridazine-3-carboxylic acid (3-methylbutyl)amide in place of 6-chloropyridazine-3-carboxylic acid (2-cyclopropyl-2-hydroxyethyl)amide to react with piperazin-1-yl-(6-fluoro-2-trifluoromethylphenyl)methanone, the title compound was obtained as a white powder (16.8% yield). 1H NMR (400 MHz, CDCl3) δ 8.06, 7.85, 7.57-7.55, 7.39-7.36, 7.01, 4.04-3.94, 3.86-3.79, 3.49, 3.44-3.36, 1.73-1.68, 1.52, 0.94.

Sources & evidence

ORD record
ord-75cf9a6cf0f8494e8c1eedc866fa8bc7
Source dataset
uspto-grants-2011_06
Patent number
US07964591B2

Reaction notes

Loading…