Acetic Anhydride → HCID 66849418, compound

HRID 2424610Notes

Reaction equation

HRID 2424610 reaction equation
[OH:1][C:2]([CH3:33])([CH3:32])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[N:9]=[N:10][C:11]([N:14]2[CH2:19][CH2:18][N:17]([C:20](=[O:31])[C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[C:27]([F:30])([F:29])[F:28])[CH2:16][CH2:15]2)=[CH:12][CH:13]=1)=[O:7].[C:34](OC(=O)C)(=[O:36])[CH3:35]>>[CH3:32][C:2]([O:1][C:34](=[O:36])[CH3:35])([CH3:33])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[N:9]=[N:10][C:11]([N:14]2[CH2:15][CH2:16][N:17]([C:20](=[O:31])[C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[C:27]([F:29])([F:28])[F:30])[CH2:18][CH2:19]2)=[CH:12][CH:13]=1)=[O:7]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 66849803HCID 66849803, compound

Product 1

HCID 66849418HCID 66849418, compound

Procedure

Following the procedure of Example 19, making variations only as required to use 6-[4-(2-trifluoromethylbenzoyl)piperazin-1-yl]pyridazine-3-carboxylic acid (3-hydroxy-3-methylbutyl)amide in place of 6-[4-(2-trifluoromethylbenzoyl)piperazin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-phenylethyl)amide to react with acetic anhydride, the title compound was obtained as a white powder (80% yield). 1H NMR (500 MHz, CDCl3) δ 8.05, 8.01, 7.75, 7.65, 7.57, 7.37, 6.99, 4.06, 3.88, 3.81-3.67, 3.58, 3.36, 2.06, 2.01, 1.52. MS (ES+) m/z 508 (M+1).

Sources & evidence

ORD record
ord-2f938813aa534b87b5650c332a886c12
Source dataset
uspto-grants-2011_06
Patent number
US07964591B2

Reaction notes

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