Formaldehyde → HCID 59345295, compound

HRID 242468Notes

Reaction equation

[CH3:1][C:2]([CH3:32])([CH3:31])[C@H:3]([NH:8][C:9]([N:11]1[C:19]2[CH2:18][CH2:17][NH:16][CH2:15][C:14]=2[C:13]([C:20]2[CH:25]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:23]=[CH:22][C:21]=2[F:30])=[N:12]1)=[O:10])[C:4]([NH:6][CH3:7])=[O:5].C=O.[CH3:35]C(C)(C)[C@H](NC(N1C2CCN(C)CC=2C(C2C=C(F)C(F)=CC=2F)=N1)=O)C(NC)=O>>[CH3:1][C:2]([CH3:32])([CH3:31])[C@H:3]([NH:8][C:9]([N:11]1[C:19]2[CH2:18][CH2:17][N:16]([CH3:35])[CH2:15][C:14]=2[C:13]([C:20]2[CH:25]=[C:24]([C:26]([F:28])([F:27])[F:29])[CH:23]=[CH:22][C:21]=2[F:30])=[N:12]1)=[O:10])[C:4]([NH:6][CH3:7])=[O:5]

Participants

Reactant 3

HCID 712Formaldehyde

HCID 46863209HCID 46863209, compound

HCID 46863441(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-5-methyl-3-(2,4,5-trifluorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide

Product 1

HCID 59345295HCID 59345295, compound

Procedure

Compound 59 was prepared reductive amination of compound 58 with formaldehyde following the procedure as described for the synthesis of compound 37. LCMS (+ESI) m/z=456.2 [M+H]+.

Sources & evidence

ORD record: ord-9867fd98b7134907aff96975b95fa663
Source dataset: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08653127B2

Reaction notes

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