Benzene, 1-chloro-3-isocyanato- → HCID 58329405, compound

HRID 2424716Notes

Reaction equation

HRID 2424716 reaction equation
C([O:3][C:4]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1[NH:16][CH:17]1[CH2:21][CH2:20][CH2:19][CH2:18]1)=[CH:13][CH:12]=[CH:11][C:10]=2[O:22][CH3:23])=O)C.[Cl:24][C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([N:31]=[C:32]=[O:33])[CH:26]=1>>[Cl:24][C:25]1[CH:26]=[C:27]([N:31]2[C:4](=[O:3])[C:6]3[CH:7]=[N:8][C:9]4[C:10]([O:22][CH3:23])=[CH:11][CH:12]=[CH:13][C:14]=4[C:15]=3[N:16]([CH:17]3[CH2:18][CH2:19][CH2:20][CH2:21]3)[C:32]2=[O:33])[CH:28]=[CH:29][CH:30]=1

Participants

3

Reactant 2

HCID 17968Benzene, 1-chloro-3-isocyanato-HCID 672497184-Cyclopentylamino-8-methoxy-quinoline-3-carboxylic acid ethyl ester

Product 1

HCID 58329405HCID 58329405, compoundYield 27.2%

Procedure

3-(3-Chloro-phenyl)-1-cyclopentyl-7-methoxy-1H-pyrimido[5,4-c]quinoline-2,4-dione (55 mg) was prepared from 4-cyclopentylamino-8-methoxy-quinoline-3-carboxylic acid ethyl ester (0.48 mmol) and 1-chloro-3-isocyanato-benzene (0.72 mmol) following general procedure C. LCMS: m/z 422 [M+1]+.

Sources & evidence

ORD record
ord-08b1d1984df342688682410c58906c54
Source dataset
uspto-grants-2011_06
Patent number
US07964608B2

Reaction notes

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