4-Chlorophenyl Isocyanate → HCID 58329470, compound

HRID 2424740Notes

Reaction equation

HRID 2424740 reaction equation
C(O[C:4]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1[NH:16][CH:17]1[CH2:22][CH2:21][CH:20]([CH3:23])[CH2:19][CH2:18]1)=[CH:13][CH:12]=[CH:11][C:10]=2[O:24][CH3:25])=[O:5])C.[Cl:26][C:27]1[CH:32]=[CH:31][C:30]([N:33]=[C:34]=[O:35])=[CH:29][CH:28]=1>>[Cl:26][C:27]1[CH:32]=[CH:31][C:30]([N:33]2[C:4](=[O:5])[C:6]3[CH:7]=[N:8][C:9]4[C:10]([O:24][CH3:25])=[CH:11][CH:12]=[CH:13][C:14]=4[C:15]=3[N:16]([CH:17]3[CH2:18][CH2:19][CH:20]([CH3:23])[CH2:21][CH2:22]3)[C:34]2=[O:35])=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 76934-Chlorophenyl IsocyanateHCID 67250000HCID 67250000, compound

Product 1

HCID 58329470HCID 58329470, compoundYield 74.5%

Procedure

3-(4-Chloro-phenyl)-7-methoxy-1-(4-methyl-cyclohexyl)-1H-pyrimido[5,4-c]quinoline-2,4-dione (55 mg) was prepared from 8-methoxy-4-(4-methyl-cyclohexylamino)-quinoline-3-carboxylic acid ethyl ester (0.164 mmol) and 1-chloro-4-isocyanato-benzene (0.25 mmol) following general procedure C. LCMS: m/z 450 [M+1]+.

Sources & evidence

ORD record
ord-1a48633c35f14cd7bdb139546c21bb97
Source dataset
uspto-grants-2011_06
Patent number
US07964608B2

Reaction notes

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