5-amino-1-(2-methoxyphenyl)-1H-pyrazole-4-carboxamide → 5-amino-1-(propan-2-yl)-1H-pyrazole-4-carboxamide

HRID 2424770Notes

Reaction equation

HRID 2424770 reaction equation
[NH2:1][C:2]1[N:6]([C:7]2[CH:12]=CC=C[C:8]=2OC)[N:5]=[CH:4][C:3]=1[C:15]([NH2:17])=[O:16].NC1N(C(C)C)N=CC=1C#N>>[NH2:1][C:2]1[N:6]([CH:7]([CH3:8])[CH3:12])[N:5]=[CH:4][C:3]=1[C:15]([NH2:17])=[O:16]

Participants

3

Reactant 2

HCID 121517035-amino-1-(2-methoxyphenyl)-1H-pyrazole-4-carboxamideHCID 179620285-amino-1-isopropyl-1H-pyrazole-4-carbonitrile

Product 1

HCID 12636095-amino-1-(propan-2-yl)-1H-pyrazole-4-carboxamide

Procedure

Following the procedure for the preparation of 5-amino-1-(2-methoxyphenyl)-1H-pyrazole-4-carboxamide but substituting 5-amino-1-isopropyl-1H-pyrazole-4-carbonitrile provided the title compound. 400 MHz 1H NMR (CDCl3) δ 7.67 (s, 1H), 4.40-4.33 (m, 1H), 1.37 (d, J=6.6 Hz, 6H). MS: (M+H m/z=169.1).

Sources & evidence

ORD record
ord-095dec868f064e06bbf67194e38d7592
Source dataset
uspto-grants-2011_06
Patent number
US07964607B2

Reaction notes

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