5-amino-1-(2-methoxyphenyl)-1H-pyrazole-4-carboxamide → 5-amino-1-cyclobutyl-1H-pyrazole-4-carboxamide

HRID 2424792Notes

Reaction equation

HRID 2424792 reaction equation
[NH2:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=CC=2OC)[N:5]=[CH:4][C:3]=1[C:15]([NH2:17])=[O:16].NC1N(C2CCC2)N=CC=1C#N>>[NH2:1][C:2]1[N:6]([CH:7]2[CH2:12][CH2:11][CH2:10]2)[N:5]=[CH:4][C:3]=1[C:15]([NH2:17])=[O:16]

Participants

3

Reactant 2

HCID 121517035-amino-1-(2-methoxyphenyl)-1H-pyrazole-4-carboxamideHCID 498535445-amino-1-cyclobutyl-1H-pyrazole-4-carbonitrile

Product 1

HCID 575563275-amino-1-cyclobutyl-1H-pyrazole-4-carboxamide

Procedure

Following the procedure for the preparation of 5-amino-1-(2-methoxyphenyl)-1H-pyrazole-4-carboxamide but substituting 5-amino-1-cyclobutyl-1H-pyrazole-4-carbonitrile provided the title compound. 400 MHz 1H NMR (CD3OD) δ 7.71 (s, 1H), 4.71-4.55 (m, 1H), 2.61-2.50 (m,2H), 2.46-2.31 (m, 2H), 1.89-1.83 (m, 2H).

Sources & evidence

ORD record
ord-16208427a5c64492910d363fb4b3edcc
Source dataset
uspto-grants-2011_06
Patent number
US07964607B2

Reaction notes

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