(Tetrahydro-2H-pyran-4-yl)hydrazine → HCID 17773354, compound

HRID 2424802Notes

Reaction equation

HRID 2424802 reaction equation
NC1N(C2C=CC=CC=2OC)N=CC=1C#N.[O:17]1[CH2:22][CH2:21][CH:20]([NH:23][NH2:24])[CH2:19][CH2:18]1.CO[C:27](=[C:29]([C:32]#[N:33])[C:30]#[N:31])[CH3:28]>>[NH2:33][C:32]1[N:23]([CH:20]2[CH2:21][CH2:22][O:17][CH2:18][CH2:19]2)[N:24]=[C:27]([CH3:28])[C:29]=1[C:30]#[N:31]

Participants

4

Reactant 3

HCID 10057480(Tetrahydro-2H-pyran-4-yl)hydrazineHCID 121505605-amino-1-(2-methoxyphenyl)-1H-pyrazole-4-carbonitrileHCID 135128392-(1-Methoxyethylidene)malononitrile

Product 1

HCID 17773354HCID 17773354, compound

Procedure

Following the procedure for the preparation of 5-amino-1-(2-methoxyphenyl)-1H-pyrazole-4-carbonitrile but substituting 1-(tetrahydro-2H-pyran-4-yl)hydrazine and 2-(1-methoxyethylidene)malononitrile provided the title compound. 400 MHz 1H NMR (CD3OD) δ 4.20 (m, 1H), 4.05 (m, 2H), 3.50 (m, 2H), 2.18 (s, 3H), 2.09 (m, 2H), 1.77 (m, 2H). MS: (M+H m/z 207.0).

Sources & evidence

ORD record
ord-b07b048ae6774b138e9857baf2acf87d
Source dataset
uspto-grants-2011_06
Patent number
US07964607B2

Reaction notes

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