3-Fluorobenzaldehyde → HCID 135886483, compound

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Following the procedure for the preparation of 6-{(3S,4S)-4-methyl-1-[(2-methylpyrimidin-5-yl)methyl]pyrrolidin-3-yl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one but substituting sodium cyanoborohydride and 3-fluorobenzaldehyde provided the title compound. 400 MHz 1H NMR (CDCl3) δ 8.02 (s,1H), 7.35-7.30 (m, 1H), 7.21-7.20 (m, 1H), 7.05 (d, J=9.5 Hz, 1H), 6.98-6.93 (m, 1H), 4.83-4.77 (m, 1H), 4.14-4.08 (m, 2H), 3.80-3.77 (m, 1H), 3.64-3.54 (m, 3H), 3.36 (t, J=8.8 Hz, 1H), 3.01 (d, J=9.9 Hz, 1H), 2.84-2.83 (m, 1H), 2.57 (m, 1H), 2.44-2.27 (m, 3H), 1.95-1.83 (m, 3H), 1.20 (d, J=7.1 Hz, 3H). MS: (M+H m/z 412.4).

Provenance & Evidence