1-Piperazinecarboxylic acid, ethyl ester → (S)-ethyl 4-(3,3-dimethyl-2-(5-methyl-3-(2,4,5-trifluorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamido) butanoyl)piperazine-1-carboxylate

HRID 242481Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 242481
NC(=O)[C@@H:3]([NH:8][C:9](=[O:37])[C@@H:10]([NH:15][C:16]([N:18]1[C:26]2[CH2:25][CH2:24][N:23]([CH3:27])[CH2:22][C:21]=2[C:20]([C:28]2[CH:33]=[C:32]([F:34])[C:31]([F:35])=[CH:30][C:29]=2[F:36])=[N:19]1)=[O:17])[C:11]([CH3:14])([CH3:13])[CH3:12])[CH2:4]C(C)C.[N:39]1([C:45]([O:47][CH2:48][CH3:49])=[O:46])CCN[CH2:41][CH2:40]1>>[CH3:14][C:11]([CH3:12])([CH3:13])[C@H:10]([NH:15][C:16]([N:18]1[C:26]2[CH2:25][CH2:24][N:23]([CH3:27])[CH2:22][C:21]=2[C:20]([C:28]2[CH:33]=[C:32]([F:34])[C:31]([F:35])=[CH:30][C:29]=2[F:36])=[N:19]1)=[O:17])[C:9]([N:8]1[CH2:41][CH2:40][N:39]([C:45]([O:47][CH2:48][CH3:49])=[O:46])[CH2:4][CH2:3]1)=[O:37]

Komponenten

3

Edukt 2

HCID 84311-Piperazinecarboxylic acid, ethyl esterHCID 46861923N-((S)-1-((S)-1-amino-4-methyl-1-oxopentan-2-ylamino)-3,3-dimethyl-1-oxobutan-2-yl)-5-methyl-3-(2,4,5-trifluorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide

Produkt 1

HCID 46862678(S)-ethyl 4-(3,3-dimethyl-2-(5-methyl-3-(2,4,5-trifluorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamido) butanoyl)piperazine-1-carboxylate

Versuchsvorschrift

Compound 77 was prepared according to the procedure described for the synthesis of compound 72 by replacing leucine amide with ethyl piperazine-1-carboxylate. LCMS (+ESI) m/z=565.4 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-a267af2aab7d4d05918f2eac2a9ec763
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08653127B2

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