HRID242482

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3772

4-Piperidinecarboxamide

C6H12N2O

结构：CC(C)C[C@H](NC(=O)[C@@H](NC(=O)n1nc(-c2cc(F)c(F)cc2F)c2c1CCN(C)C2)C(C)(C)C)C(N)=O

HCID46861923

未命名化合物

PRODUCTS

生成物

结构：CN1CCc2c(c(-c3cc(F)c(F)cc3F)nn2C(=O)N[C@H](C(=O)N2CCC(C(N)=O)CC2)C(C)(C)C)C1

HCID46862034

未命名化合物

PROCEDURE

实验过程

Compound 79 was prepared according to the procedure described for the synthesis of compound 72 by replacing leucine amide with piperidine-4-carboxamide. LCMS (+ESI) m/z=535.4 [M+H]+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3ae89cbda67b4e739fed19fc6445a8f0
来源数据集: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08653127B2
来源说明: uspto-grants-2014_02

反应 SMILES

NC(=O)[C@@H:3]([NH:8][C:9](=[O:37])[C@@H:10]([NH:15][C:16]([N:18]1[C:26]2[CH2:25][CH2:24][N:23]([CH3:27])[CH2:22][C:21]=2[C:20]([C:28]2[CH:33]=[C:32]([F:34])[C:31]([F:35])=[CH:30][C:29]=2[F:36])=[N:19]1)=[O:17])[C:11]([CH3:14])([CH3:13])[CH3:12])[CH2:4]C(C)C.N1CC[CH:42]([C:45]([NH2:47])=[O:46])[CH2:41][CH2:40]1>>[C:45]([CH:42]1[CH2:41][CH2:40][N:8]([C:9](=[O:37])[C@@H:10]([NH:15][C:16]([N:18]2[C:26]3[CH2:25][CH2:24][N:23]([CH3:27])[CH2:22][C:21]=3[C:20]([C:28]3[CH:33]=[C:32]([F:34])[C:31]([F:35])=[CH:30][C:29]=3[F:36])=[N:19]2)=[O:17])[C:11]([CH3:14])([CH3:12])[CH3:13])[CH2:3][CH2:4]1)(=[O:46])[NH2:47]