3-Amino-1-propanol → (S)-N-(1-(3-hydroxypropylamino)-3,3-dimethyl-1-oxobutan-2-yl)-5-methyl-3-(2,4,5-trifluorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	3-Amino-1-propanol	HCID 9086	—
Reactant	N-((S)-1-((S)-1-amino-4-methyl-1-oxopentan-2-ylamino)-3,3-dimethyl-1-oxobutan-2-yl)-5-methyl-3-(2,4,5-trifluorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide	HCID 46861923	—
Product	(S)-N-(1-(3-hydroxypropylamino)-3,3-dimethyl-1-oxobutan-2-yl)-5-methyl-3-(2,4,5-trifluorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide	HCID 46862035	—

Reaction Steps

Compound 80 was prepared according to the procedure described for the synthesis of compound 72 by replacing leucine amide with 3-amino-propan-1-ol. LCMS (+ESI) m/z=482.3 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08653127B2
Source dataset	uspto-grants-2014_02
ORD ID	ord-c3dffbb84ccc4aa0b560514b67c10aec
Source note	uspto-grants-2014_02