HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidin-4-ol → HCID 25015093, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidin-4-ol | HCID 79341 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (3S)-pyrrolidin-3-ol | HCID 2733874 | — |
| Reactant | 2,6-Dichloro-N-{[(1S,3S)-1-hydroxy-3-methylcyclohexyl]methyl}quinoline-5-carboxamide | HCID 86623364 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 25015093 | HCID 25015093 | — |
Reaction Steps
The title compound was prepared by the method of Example 1, step e) by reacting piperidin-4-ol (28 mg) (instead of (S)-3-hydroxypyrrolidine) with the product of Example 1, step d) (0.10 g) and diisopropylethylamine (0.11 g) in acetonitrile (2 ml) to afford the title compound as a white solid (99 mg). m.p. 120° C. dec.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07964616B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-5356ab1051114a988bf4a6eedd3ff8cf |
| Source note | uspto-grants-2011_06 |