Water → 1-Benzyl-3-methylpyrrolidin-3-OL

Participants

Reaction Steps

Methylmagnesium bromide (4 ml of 3M solution in diethyl ether) was added dropwise to a solution of 1-benzylpyrrolidin-3-one (1.75 g) in tetrahydrofuran (50 ml) at 0° C. The mixture was stirred at 0° C. for 1 hour before water and diethyl ether were added and the layers separated. The organic layer was washed with brine, dried (MgSO4), filtered and concentrated in vacuo. The crude material was purified by flash column chromatography (SiO2, 5% methanol/dichloromethane as eluent) to afford the subtitle compound as a pale brown oil (0.8 g).

Provenance & Evidence