2,5-Difluorobenzoyl chloride → (S)-2-(3-(2,5-difluorophenyl)-5-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamido)-3,3-dimethylbutanoic acid

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	2,5-Difluorobenzoyl chloride	HCID 588082	—
Edukt	(S)-3,3-dimethyl-2-(5-methyl-3-(2,4,5-trifluorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamido)butanoic acid	HCID 46861922	—
Produkt	(S)-2-(3-(2,5-difluorophenyl)-5-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamido)-3,3-dimethylbutanoic acid	HCID 46862776	—

Reaktionsschritte

Compound 81 was prepared according to the procedure described for the synthesis of compound 71 by replacing 2,4,5-trifluorobenzoyl chloride with 2,5-difluoro-benzoyl chloride in the synthesis of intermediate 19. LCMS (+ESI) m/z=407.2 [M+H]+.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08653127B2
Quelldatensatz	uspto-grants-2014_02
ORD ID	ord-1f330cca793645e39367c31670f98779
Quellennotiz	uspto-grants-2014_02